Psoriatic Arthritis

Psoriatic arthritis is a chronic (long-term), progressive, inflammatory arthritis (swelling and tenderness of the joints). People with it can have swollen, tender joints, as well as nail changes, and the scaly, raised, red skin changes of psoriasis.


Inflammation most commonly involves the joints of the hands, wrists, neck, back, knees, ankles and feet. The pain and stiffness are usually worse in the morning, or after rest, and can improve with physical activity. The severity can vary from mild disease affecting only a few joints without any noticeable pain to severe disabling and painful arthritis with deformity and destruction of joints. In people with mild arthritis, the condition can remain undiagnosed and might have minimal impact on their quality of life. More severe forms of can occur in people with multiple affected joints (more than four), and in younger, often female patients. Early diagnosis and treatment is important to prevent destruction and deformity of the joints.


In most people, the skin lesions of psoriasis usually occur before arthritis develops. Less commonly, arthritis can occur at the same time or before skin changes occur. In the past, it was believed that approximately 5 percent of patients with psoriasis had psoriatic arthritis. Recent research has determined that approximately 15 to 30 percent of patients with psoriasis do develop psoriatic arthritis.

It belongs to a group of conditions known as seronegative spondyloarthropathies. The term "seronegative" means that the blood (sero) is negative for a certain factor present in rheumatoid arthritis. The blood test is for the rheumatoid factor, which is a protein found in the blood of most patients with another type of arthritis called rheumatoid arthritis. The term "spondylo" means spine, and "arthropathy" means painful, swollen joints. Spondyloarthropathy refers to a group of conditions that share several features, including:

  • a pattern of arthritis that affects the spine and extremities;
  • inflammation of ligaments and tendons;
  • inflammation of other organs such as the eye;
  • evidence of a family inheritance.
  • In the past,it may have been under recognized. Also, accurate data has been difficult to gather for several reasons:

  • Patients with might not feel much pain, so the disease can go unnoticed until it has progressed and
        there are deformities.
  • This form of psoriasis can be a difficult type of arthritis to diagnose, and doctors may misdiagnose it
        for another form of arthritis. There has been a lack of widely accepted criteria for diagnosing
        psoriatic arthritis.
  • New criteria are currently being developed by rheumatologists to assist in diagnosing and assessing
        psoriatic arthritis.
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